Pathological jaundice appears early in newborns, starting 24 hours after birth and lasting longer. In some children, jaundice persists and does not subside, or even worsens. It does not subside for a month, and this condition is generally considered pathological jaundice. Symptoms of pathological jaundice in newborns include the following: 1. Serum bilirubin may exceed normal values, greater than 220.59 μmol/L in full-term infants and greater than 255 μmol/L in preterm infants. 2. Skin yellowing: golden yellow, or orange skin, with significant yellowing of the face, body, sclera (the white part of the eyes), palms, and soles of the feet. Yellow staining is the most powerful symptom feature to determine jaundice. The order of yellowing is from the face to the chest, then to the trunk and extremities, and in severe cases, the palms of the hands and feet are yellow. The baby’s urine deepens in color, becoming dark yellow, tea-colored or even soy sauce-colored. The stool becomes lighter in color, turning white or white clay. 3, Some children with persistent jaundice that does not subside or even worsens, more than 2 weeks for full-term babies and more than 4 weeks for premature babies. 4, pathological jaundice of children, serious can appear some complications, such as nuclear jaundice, nuclear jaundice is bilirubin encephalopathy. 5.When nuclear jaundice occurs, the child’s jaundice will be significantly aggravated, manifested as drowsiness, lack of strength to suck milk, or choking, and changes in muscle tone. 6. In severe cases, children may moan, scream or even convulse, and develop serious symptoms such as respiratory failure. In this case, the condition changes quickly and can easily lead to death. Even if the symptoms can be relieved with treatment, some children can develop brain or intellectual damage, appearing as mental retardation or cerebral palsy and other sequelae.