The application of laparoscopy-guided percutaneous puncture or small-incision surgery with argon helium supercooled knife for single or multiple tight tumors is safe and effective. It can reduce damage to normal renal parenchyma, significantly reduce postoperative complications and shorten hospital stay. Minimally invasive targeted treatment with argon helium supercooled knife is an ideal approach for the treatment of localized multiple tumors in the kidney. Compared with surgery or laparoscopic partial nephrectomy, cryotherapy for small renal tumors has the advantages of shorter treatment time and fewer complications; compared with radiofrequency ablation, cryotherapy has the advantages of requiring less pain-relieving anesthetics and more complete target tissue necrosis. Therefore, cryopreservation is promising to be the first choice of minimally invasive therapy for small renal tumors. The selection of cryopreservation method can be based on the following principles: 1.Single superficial small kidney cancer: laparoscopic cryopreservation; 2.Multiple kidney cancer, tumors near the kidney gate: intraoperative cryopreservation; 3.Small kidney cancer, single or not more than 3, patient’s general condition is poor: percutaneous cryopreservation; 4.Local progressive kidney cancer: patient’s general condition is good, intraoperative cryopreservation, and for those who have metastasis, percutaneous cryopreservation is used to achieve palliative effect.