1. Indigestion, bloating and diarrhea. As far as is known, the gallbladder has at least the functions of storage, concentration and contraction. Of course, it also has complex chemical and immune functions. Bile is secreted by hepatocytes through capillary bile ducts, small bile ducts, left and right bile ducts, common hepatic ducts, along the cystic duct, into the gallbladder for storage and concentration. The concentrated bile is 30 times more concentrated than hepatic bile and is reserved for high-fat meals before being discharged into the intestine to participate in digestion. If the gallbladder has been removed, here the liver bile from the liver discharge can not be stored, regardless of whether the human body needs, have to be continuously discharged into the intestine; to go to a banquet to eat sorghum thick taste, a lot of bile to help digestion, but at this time the body has no “surplus bile” to help, the symptoms of indigestion. 2.Gastric reflux of duodenal fluid after cholecystectomy, reflux of gastric fluid esophagus. In recent years, there have been many reports on Duodenogastric Reflux DGR and gastric reflux after cholecystectomy, and Walsh et al. also confirmed in a controlled study that all markers were refluxed to the gastroesophagus after cholecystectomy, accompanied by a significant decrease in the tone of the lower esophageal sphincter; Chen MF et al. The loss of bile reserve function causes bile to change from intermittent and feeding-related excretion to continuous excretion into the duodenum, which increases the chance of reflux into the stomach and produces DGR. it leads to bile reflux gastritis or esophagitis, which brings a lot of pain to patients. 3.The effect of cholecystectomy on the incidence of colon cancer. In recent years, many European scholars found a phenomenon and doubt that among cases suffering from colon cancer, many cases were found to have a history of cholecystectomy. In Moorehead’s analysis of 100 cases of cholecystectomy over 60 years old, 12 cases of colon cancer were found; while in another 100 cases without cholecystectomy, there were only 3 cases of colon cancer patients. 4.In addition, gallbladder resection is very easy to cause bile duct injury, some people count 500,000 cases of gallbladder resection in China every year, if we calculate according to the lower chance of 0.5% of common bile duct injury, there will be 2500 cases of common bile duct injury in China every year, if it happens to you, it is 100% reality.