Placement of PICC line for chemotherapy may cause adverse reactions such as puncture site oozing, bleeding, phlebitis, venous thrombosis, etc. 1. Puncture point oozing and bleeding: the main manifestation is yellow liquid oozing from the puncture site, there may be oozing blood, which will penetrate the dressing, and in serious cases, it may cause infection and ulceration of the surrounding skin. 2. Phlebitis: the main manifestation is the appearance of striated changes above the puncture site, local skin redness, swelling, pain and striated marks. 3. Venous thrombosis: the introduced catheter may damage the vascular endothelium and form thrombus, leading to obstruction of venous return, which may lead to swelling of face, neck and shoulders, local skin changes, numbness of limbs, etc., and may lead to pulmonary embolism in severe cases. If adverse reactions occur after chemotherapy tube placement, you should seek medical attention promptly to avoid delays.