Most cases of ophthalmoplegia are caused by staphylococcal infections, with Staphylococcus aureus being the most common. Macroglossia is an acute, painful, purulent, nodular inflammatory lesion of the eyelid glands, medically known as blepharitis. A large swollen area forms when the lid gland is involved as endophthalmitis; an infection of the sebaceous or sweat glands of the eyelid is exophthalmitis, where the swelling is small and superficial. Blepharitis with blepharitis may present as multiple lesions or recurrent episodes. The development of infectious disease is generally associated with two factors. (1) Contact with pathogenic bacteria: The pathogens are mostly staphylococci, which mostly enter the gland via the lid gland at the opening of the lid margin and cause inflammation. This is often due to the patient’s lack of hand hygiene and rubbing of the eyes with dirty hands, etc. Infection with pathogenic bacteria can occur. (2) Patient’s resistance: Children and elderly people and patients with chronic wasting diseases such as diabetes and low resistance are prone to wheals, and female patients with decreased resistance due to factors such as menstruation or recent late nights are prone to wheals, and the wheals that appear are prone to progress and have a strong inflammatory response. In summary, wheals in the eyes are caused by a decrease in the patient’s resistance to certain conditions, while pathogenic bacteria such as staphylococcus invade the eyelid glands and form an acutely painful, purulent nodular swelling on the eyelid.