When fever occurs in advanced stage of lung cancer, it depends on how many degrees the temperature is. It may be because lung cancer is accompanied by heavy obstructive pneumonia, and this condition will cause fever, which is the result of the combined effect of inflammation and tumor. If the body temperature is higher than 38.5 degrees, antipyretic drugs such as ibuprofen are needed. If the body temperature is not higher than 38.5 degrees, it belongs to low fever, so physical cooling can be used first, together with Chinese medicine for clearing heat and detoxifying, such as Xinhuang tablets, which may also be effective. And for the primary lesion of lung cancer, further treatment is also needed, depending on the patient’s physical condition, together with radiotherapy, chemotherapy, interventional treatment and so on. If the development of the disease can be controlled, it is also possible to relieve the symptoms of fever. For example, if there is mutation in lung adenocarcinoma, targeted therapy can be used if there is mutation in genetic test, which is beneficial to shrink the tumor lesion and control the disease development, and also can relieve other symptoms such as fever.