Patients with advanced stage of squamous lung cancer usually have lost the chance of surgical resection, and the treatment is usually based on chemotherapy, supplemented by radiotherapy, immunotherapy, targeted therapy, etc. to relieve the symptoms; the specific treatment plan should be chosen according to the cause of the disease and the individual’s physical condition, and there is no such thing as “the best”, so please comply with the doctor’s instruction to standardize the treatment. 1. Chemotherapy: It can be used in advanced stage of squamous lung cancer, commonly used drugs include cisplatin, gemcitabine, pemetrexed, paclitaxel, docetaxel, etoposide and irinotecan, etc., which can kill the cancer cells or stop their growth through chemical drugs. 2. Radiotherapy: for patients with advanced squamous lung cancer, radiotherapy aims at inhibiting tumor development, delaying tumor spread and relieving symptoms. 3. Immunotherapy: killing cancer cells by enhancing the body’s immune response, especially PD-1/PD-L1 inhibitors, which can enable a few advanced patients to achieve long-term survival. 4. Targeted therapy: mainly targeting the specific or relatively specific molecules of tumor cells, applying molecular targeted drugs to specifically block the biological function of the target, so as to achieve the purpose of inhibiting tumor growth or even tumor regression. It is recommended that patients follow the doctor’s instructions to actively treat the tumor and adjust their emotions in daily life to face the disease with a positive attitude. Please strictly follow the doctor’s instructions for medication, and do not use medication on your own.