Antihypertensive drugs that have little effect on the liver mainly include angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and alpha-blockers. 1. Angiotensin-converting enzyme inhibitors: they are mainly used in the treatment of hypertension, such as perindopril and fosinopril. 2. Calcium antagonists: calcium antagonists mainly act on the vascular smooth muscle tissue, which can make the blood vessels diastolic and achieve the purpose of lowering blood pressure, and will not have an effect on the liver, commonly used drugs are nifedipine, amlodipine and so on. 3. β-blocker: β-blocker can block the β-receptor of myocardial tissue and reduce heart rate and myocardial contractility, there are medicines such as metoprolol, bisoprolol, etc., which do not have much effect on the liver. 4. α-blockers: α-blockers have relatively minor side effects, such as terazosin, uradil and other drugs, and do not have much effect on the liver. These antihypertensive drugs are commonly used in the clinic, and need to be taken correctly according to the doctor’s instructions, in order to maintain the stability of blood pressure and play a good role in lowering blood pressure.