The skull is a very important group of bone tissues in the human body, which plays an important role in protecting and supporting the brain and head and facial organs. But danger exists everywhere, there may be many accidents in our life that may cause threat and injury to our skull. For example, traffic accidents, manufacturing accidents, falling objects, etc., may cause cranial defects. Cranial defects may have a great adverse effect on the human body, especially when the area of the defect is relatively large. First of all, it affects the aesthetics, and it is also very unsafe, because the lack of hard skull protection may make the brain more vulnerable to external damage; another important point is that after skull defect, the intracranial environment will change, the intracranial pressure will be unstable, the cerebrospinal fluid circulation and blood circulation may be impaired, and the neurological function may be damaged, causing a series of symptoms. Therefore, skull repair should be performed in time after skull defect. Cranial defect can cause great damage to human body, so it should be repaired in time. Currently, our team is using advanced PEEK material to perform PEEK cranial repair, and we have achieved excellent results in clinical practice. After PEEK skull repair, not only can we recreate a complete closed cranial environment, ensure normal cerebrospinal fluid circulation and blood circulation in the brain, maintain normal brain nerve function, and help restore some discomfort symptoms, but also add the concept of cosmetic surgery, so that the postoperative patient’s skull shape is symmetrical on both sides, beautiful and natural, which is well received by patients.