Waking up in the morning and having diarrhea may be caused by food poisoning, irritable bowel syndrome, hyperthyroidism, etc. Consult your doctor for specifics, and follow the doctor’s instructions for medication and, if necessary, surgical treatment. 1. Food poisoning: patients need to rest in bed, if the patient has symptoms of abdominal cramps, you can take belladonna tablets to relieve the symptoms. Individual patients may also have allergic symptoms, which need to be combined with the use of antihistamine drugs such as diphenhydramine and loratadine. If the patient’s diarrhea is severe, then the patient can take Montelukast and so on for treatment. For patients with neurological food poisoning, 5% sodium bicarbonate, 1:4000 potassium permanganate solution should be used as soon as possible for enema and gastric lavage. 2. Irritable bowel syndrome: usually patients can follow the doctor’s instructions to use scopolamine, pivoxyline, pivoxyl bromide and other antispasmodic agents, some patients can also be used with the use of loperamide, cotrimoxazole and other antidiarrheal agents or alosetron and other kinetic sensory modifiers treatment. If the patient has mental abnormal symptoms, can also use fluoxetine, paroxetine and other antidepressant treatment. 3. Hyperthyroidism: Usually, patients can follow the doctor’s instructions to use methimazole, propylthiouracil and other antithyroid drugs, patients can also use propranolol and other beta-blockers for treatment. If the patient’s condition is more serious, partial or total thyroidectomy is also needed. It is recommended that patients who have diarrhea after waking up in the morning and having the first bowel movement, should consult a doctor in time for examination and treatment according to the cause of the disease under the guidance of the doctor.