Our clinical observation found that in the early stage of severe hepatitis B, the common clinical symptoms are high degree of malaise, obvious abdominal distension and other non-specific symptoms, along with yellow urine, and the urine color is deepening every day. At this time, hepatocytes may not have died in large numbers, mainly manifesting as degenerative edema, while the patient’s liver function showed a sharp decline and a sharp increase in ALT, which we call this period as the degenerative failure stage, which is very different from the staging of early, middle and late stages on the domestic 2011 version of liver failure guidelines. Its clinical features are: 1. rapid increase in transaminases, ALT>1000U/L, 2. low or rapidly decreasing coagulation, PTA<40%, or INR>1.5. 3. rapid rise in jaundice, elevated more than 17μmol/l. per day, but total bilirubin is not necessarily greater than 171μmol/l. 4. may be combined with hepatic encephalopathy stage I to II. 5, No obvious infection exists. Previous clinical studies also suggest the existence of this condition. If the further development of hepatitis cannot be stopped at this stage, it will be very difficult to treat when it enters the stage of necrotic failure of liver function with necrosis as the main manifestation. For this reason, immediate medical attention should be sought if any of these conditions occur. Once this period is missed to enter the necrotic failure stage, the average mortality rate of the disease will reach 40%. In severe cases (patients with PTA < 20%) without liver transplantation, the mortality rate of medical treatment is 90%, and artificial liver does not work well for the disease.