Pancreatic schizophrenia is a congenital abnormality of pancreatic development that is characterized by the lack of fusion of the main and secondary pancreatic ducts. In a normally developing pancreas, the main and secondary pancreatic ducts merge into the duodenum or there is no more than one branch of the secondary pancreatic duct. However, when the pancreas has congenital developmental abnormalities, the main pancreatic duct and the secondary pancreatic duct of the pancreas will converge into the duodenum or there will be more than one branch of the secondary pancreatic duct, resulting in obvious narrowing of the opening of the pancreatic duct, which is clinically known as pancreatic schizophrenia. Pancreatic schizophrenia, due to congenital variations in the opening of the pancreatic duct or narrowing of the opening of the pancreatic duct, can lead to poor drainage of pancreatic juices, resulting in easy reflux of pancreatic juices, causing increased pressure in the pancreatic duct, which is mostly manifested as pancreatitis in the clinic. No treatment is needed for those without obvious symptoms; mild symptoms can be treated symptomatically; if pancreatitis is more serious and stenosis is obvious, stent intervention can be considered. In order to detect pancreatic schizophrenia in time, it is recommended to have regular medical checkups, and to have regular treatment as soon as possible after discovery.