There are many causes of cough in the middle of the night, mainly cough variant asthma, allergic cough, gastroesophageal reflux disease, etc., according to different conditions need to choose the corresponding drugs for treatment. 1. Cough variant asthma: it can be manifested as irritating dry cough at night, commonly used therapeutic drugs are budesonide formoterol powder inhaler, montelukast and so on. 2. Allergic cough: such as dust mites, pollen and other allergens can cause allergic cough, easy to aggravate cough at night, commonly used drugs are loratadine, cetirizine and other anti-allergy drugs. 3. Gastroesophageal Reflux Disease (GERD): Cough caused by acid reflux into the throat after sleeping flat on the back, commonly used drugs are omeprazole, mosapride and so on. Causes of nocturnal cough may also have other diseases, such as heart failure, etc. It is recommended that if the symptoms are not relieved or aggravated, go to a regular medical institution for timely consultation and examination, to clarify the cause of the disease, follow the doctor’s instructions to take medication, and do not take medication privately.