Currently, the commonly used antihypertensive drugs are divided into five categories. Short-acting antihypertensive drugs are mostly used for rapid blood pressure lowering when blood pressure increases, and need to be taken 2-3 times a day for a long time, such as dihydropyridine calcium antagonist nifedipine and angiotensin converting enzyme inhibitor captopril. In order to make the blood pressure better achieve the standard, in the antihypertensive treatment is now mostly used in the long-acting preparations, this is because the long-acting preparations can be 24 hours of smooth antihypertensive, to avoid blood pressure fluctuations, can effectively control the whole day blood pressure and morning peak blood pressure, so as to more effectively prevent the occurrence of cardiovascular events, and easy to take, the number of times to take less, once a day. In contrast, short-acting formulations of antihypertensive drugs need to be taken 2-3 times a day, which is easy to miss or wrongly take leading to large fluctuations in blood pressure and increasing the risk of cardiovascular events. In short, in hypertension antihypertensive treatment should be individualized according to the type of special population, comorbidities, and selection of targeted drugs.