The hepatitis B virus is transmitted from mother to child to pregnant women: 1, pregnant women with a history of close contact with hepatitis B, first injected with hepatitis B immunoglobulin (HBIG), and screened for HBsAg, anti-HBs antibody and anti-HBc antibody. 3 negative pregnant women can be injected with hepatitis B vaccine. 2. Pregnant women with hepatitis B can receive one intramuscular injection of hepatitis B high-valent immunoglobulin in each of the seventh, eighth and ninth months of pregnancy. 3, HBsAg and HBeAg-positive pregnant women should strictly implement the disinfection and isolation system when giving birth. Prevent birth injuries, neonatal injuries and amniotic fluid aspiration to reduce vertical transmission. Interruption of mother-to-child transmission of hepatitis B: After birth, the fetus should be injected with hepatitis B high potency immunoglobulin (HBIG) and hepatitis B vaccine. 1.Active immunization: newborns are given 30ug of hepatitis B vaccine intramuscularly within 24 hours after birth, and 10ug after birth, 1 month and 6 months respectively. newborns have a good immune response to the vaccine and anti-HBs antibodies are produced in their bodies, which can effectively protect their liver from HBV infection, with a 75% immunization success rate. 2.Passive immunization: Immediately after birth, newborns are given intramuscular injection of HBIG 0.5ml, and then 0.16ml/kg each at 1 month and 3 months after birth, especially for babies born to mothers with hepatitis B, which can reduce or prevent HBV from entering the liver. 3. Combined immunization: Hepatitis B vaccine is administered as described above, and HBIG is replaced by a single intramuscular injection of 0.5 ml within 24 hours after birth. Passive immunity is obtained before active immunity is established. Make the effective protection rate reach 94%.