Sudden generalized soreness and weakness are generally considered to be caused by pre-infection, rhabdomyolysis, cold stimulation, electrolyte balance disorders and so on. 1. Pre-infection: for example, bacteria, viruses, fungi, etc. infect the body, release inflammatory mediators, patients may appear symptoms of generalized pain and weakness. In this case, the patient should measure the body temperature, also need to do blood routine and other related examinations. 2. Rhabdomyolysis: Rhabdomyolysis may be caused by medication, summer heat stroke, pyrexia, etc. Patients may have sudden generalized pain and weakness. If it is caused by medication, the patient will usually get better after stopping the medication. 3. Cold stimulation: patients may have symptoms of generalized pain and weakness. Patients should pay attention to keep warm and keep away from bad factors. 4. Electrolyte balance disorders: for example, patients with hypokalemia and hyponatremia may have sudden generalized pain and weakness. Patients should do electrolyte examination and laboratory examination. If it is caused by hypokalemia, supplementation of potassium ions will improve. Patients with sudden generalized soreness and weakness need to consult a doctor in time to clarify the cause of the disease and then treat it to avoid delaying the condition.