poems syndrome is a chronic progressive multiple sensorimotor neuropathy, which is relatively rare and is a paraneoplastic syndrome. Poems syndrome has a chronic onset with an average age of 46 years and may present with the following symptoms: 1. organ enlargement, such as enlarged liver, spleen and lymph nodes; 2. endocrine symptoms, such as diabetes mellitus and hypothyroidism; 3. monoclonal plasma cell proliferative disorders, such as giant lymph node hyperplasia and reactive hyperplasia; 4. skin damage, such as hyperpigmentation and Raynaud’s phenomenon; 5. sensory distal extremities Abnormalities with weakness, progressive aggravation and progression to the proximal extremities, glove-sock-like sensory impairment, and diminished or absent tendon reflexes in the extremities. The treatment of poems syndrome is based on a comprehensive assessment of the patient. If the patient shows limited bone damage and no clonal plasma cells are found by bone aspiration, radiotherapy is preferred; if clonal plasma cells are found, systemic chemotherapy is required. (Please consult a specialist at a regular hospital for specific medications). The disease can progress rapidly or slowly, and the prognosis is poor when the disease progresses rapidly and has a high number of comorbidities.