Prolonged use of venlafaxine may lead to gastrointestinal discomfort symptoms, increased blood pressure, induction of epilepsy or dependence. 1. Gastrointestinal discomfort: mainly because the drug may cause some damage to the gastric mucosa, which may lead to nausea, anorexia and other symptoms, and may also cause diarrhea. 2. Increased blood pressure: most patients take it according to the dosage, which will not cause changes in blood pressure, but if it is not taken properly, it may lead to increased blood pressure. 3. Induce epilepsy: A few patients may induce epilepsy when taking the drug in high doses. 4. Produce dependence: Venlafaxine is an antidepressant drug, if taken for a long period of time, there is a risk of dependence sudden discontinuation of the drug causing withdrawal reactions, such as insomnia and anxiety. It is contraindicated for those who are allergic to this product and the ingredients contained in it, and its combination with monoamine oxidase inhibitors is prohibited. It should not be used by pregnant and lactating women, or children under 18 years of age. Venlafaxine must be taken under the supervision of a doctor, not to be used at will, and not to increase or decrease the dosage at will.