The safe range for anti-phospholipase A2 receptor antibody concentrations is generally below 20 Ru/mL. Phospholipase A2 receptor (PLA2R) on glomerular podocytes is the target antigen of idiopathic membranous nephropathy. Circulating anti-PLA2R antibody binds to PLA2R on glomeruli and becomes an in situ immune complex, which activates complement leading to podocyte damage, resulting in the production of urinary protein. The sensitivity of anti-PLA2R antibody for diagnosing membranous nephropathy is about 80% and the specificity is up to 99%, which is a specific diagnostic index for idiopathic membranous nephropathy. In addition, the level of anti-PLA2R antibody is closely related to the clinical disease activity, and the change of antibody level is consistent with the clinical outcome, which is a good indicator to predict the disease process. If the concentration of anti-phospholipase A2 receptor antibody is found to be high, it is recommended that the patient should go to the regular hospital for consultation, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.