Anti-cardiolipin antibody syndrome often manifests clinically as thrombosis, which is often most prevalent in small and medium-sized vessels, and can form in both arteries and veins, with venous thrombosis being more common. This condition should be treated aggressively, mainly with anticoagulation and antiplatelet therapy, including the use of antiplatelet therapy drugs such as aspirin, heparin, and warfarin. Sometimes hormonal drugs should also be used in case of definite thrombocytopenia or autoimmune hemolytic anemia, as well as in critical cases of life-threatening anti-cardiolipin antibody syndrome or transsphenoidal myelopathy. In the period of acute thrombosis, long-term anticoagulation therapy with heparin or new oral anticoagulants should be used.