Stage III syphilis, also known as advanced syphilis, is usually treated with medication, surgery, and general measures. 1. Drug treatment: patients need to follow the doctor’s advice to choose benzylpenicillin or procaine penicillin G and other antibiotic treatment. If the patient is allergic to penicillin antibiotics, then the patient can follow the doctor’s advice to choose ceftriaxone sodium, doxycycline and other antibiotics. 2. Surgical treatment: Aortic valve replacement is required for those with syphilitic aortic insufficiency in stage III syphilis. For those with coronary artery stenosis, coronary artery bypass surgery, coronary artery dilatation and other surgical treatments are needed. 3. General measures: patients need to correct their mentality, keep their mood happy and face the disease correctly. Usually need to pay attention to protect the skin damage parts, prohibit scratching, but also need to actively exercise, enhance physical fitness, improve immunity. Patients with stage 3 syphilis need to go to the hospital in a timely manner, cooperate with the doctor to actively treat the disease, strengthen the management of daily life, and follow up on time, so that the doctor can monitor the changes in the condition.