Granulomatous hyperplasia of duodenum usually do not need surgical treatment, can use medication under the guidance of the doctor, at the same time need regular follow-up, if there is the possibility of malignant transformation should be timely surgical treatment. Duodenal bulb granulomatous hyperplasia is not a very serious disease, usually do not need surgical treatment, you can take oral acid-suppressing drugs such as omeprazole, protect the gastrointestinal mucosa of the drug such as thioglycollate suspension, etc., and if there is a Helicobacter pylori infection, the need for anti-infective treatment. At the same time, patients need to establish good living and dietary habits, regular work and rest, diet should be light, avoid spicy and irritating as well as fried food. In addition, patients should undergo regular checkups to observe the changes in their condition. If severe heterogeneous hyperplasia of the intestinal mucosal epithelium occurs, there is a certain possibility of malignant transformation, which requires surgical treatment, such as gastroscopic laser cauterization, mucosal resection of the lesion, and surgical resection. Therefore, it is recommended that patients suffering from duodenal bulb granulomatous hyperplasia follow the doctor’s instructions for treatment, so as not to delay the condition.