Antibiotics have certain side effects, the most common is allergic reaction, the patient will appear around the body rash or perioral numbness, and in serious cases may also appear nerve or blood vessel edema, should be promptly discontinued. Antibiotics for a long period of time are prone to drug resistance, or lead to disorders of the body flora, especially the intestinal flora will lead to diarrhea. The drug is usually metabolized by the liver and kidneys, and some people may experience increased transaminases, abnormal bilirubin, or increased creatinine and urea nitrogen. For patients with chronic diseases who have been on medication for a long time, attention should be paid to monitoring changes in biochemical indicators, and if the condition allows during medication, more water should be consumed to speed up the metabolism of drugs. Attention should be paid to monitoring the occurrence of adverse drug reactions, targeted selection of drugs.