MRAs are called salicorticoid receptor antagonists, and their treatment of heart failure is true, and these drugs are often used as one of the standard medications in the treatment of heart failure. Salt corticosteroid receptor antagonists mainly include spironolactone, eplerenone two kinds of drugs, used in the treatment of heart failure, it can effectively reduce the occurrence of cardiovascular adverse events, reduce mortality. Moreover, these drugs treat heart failure with minimal effect on blood pressure. Spironolactone is often used in combination with diuretics, which can improve furosemide-induced hypokalemia due to its potassium-preserving effect. However, these drugs tend to cause high blood potassium and should be used with caution in patients with severe renal insufficiency or hyperkalemia. It is recommended to use under the guidance of physicians.