Mild protective and emollient agents are appropriate in the acute phase of psoriasis; drugs with stronger effects are available in the stable and receding phases, but should be started at low concentrations. Usually daily. ①Emollient: petroleum jelly, glycerin, mineral oil, urea, etc. ② keratinizing agents: 2% to 5% coal tar or bran distillate, 5% to 10% black bean distillate, 3% salicylic acid, 3% to 5% sulfur, 0.1% to 0.5% dithranol, 0.001% carbotriol ointment, 5% fish lithin. Peng Shaowen, Department of Dermatology, General Hospital of Beijing Military Region ③Keratolytic agents: 5%-10% salicylic acid, 10% rezosin, 10% sulfur, 20% urea, 5%-lo% Vulinic acid, o.1% vincristine, 10%-30% ichthyolipid. Glucocorticoids: low potency: 0.5%-2.5% hydrocortisone acetate, 0.25%-l% methylprednisolone; medium potency: 0.1% hydrocortisone butyrate, 0.1% dexamethasone, 0.1% tretinoin, 0.03% flumethasone pivalate, 0.1% mometasone furoate; strong potency: 0.5% botrytisine, 0.1% betamethasone valerate, 0.1% harcionide; extra strong potency: 0.05% clobetasone propionate. 0.05% clobetasol propionate, 0.05% halometasone, 0.05% difluazone. ⑤ Vitamin A acid class: 0.025% a 0.1% all-trans vitamin A acid, 0.05% isotretinoin, 0.1% adapalene gel, 0.01%, 0.05% and 0.1% tazarotene, etc. (6) Vitamin D3 derivatives: carboxytriol, tacalcitol, osteoporotic triol. (7) Dithranol: 0.1% to 0.5% dithranol ointment, cream, paste and compound preparation. (8) Tar: 5% coal tar, l%-5% coal tar, 5%-10% black bean distillate, 5% bran distillate. ⑨ cytotoxic drugs: 0.05% aqueous solution of nitrogen mustard hydrochloride or ethanol solution. ⑩Other: 0.01% a 0.025% chorine ointment, 10% a 15% camptothecin, etc. Tazarotene, medium- and strong-acting glucocorticosteroids, and carboplatinol can be used as the first-line drugs for local treatment.