There are currently dozens of World Disease Days, and there are four World Disease Days related to dermatology, namely: World Leprosy Day – the last Sunday of January each year, World Allergy Day – July 8, World AIDS Day – December 1, and World Psoriasis – October 29. Leprosy is an ancient worldwide infectious disease with a clear cause and a potent treatment, the incidence of which has declined significantly and is likely to be largely eradicated in the near future. Allergic diseases involve dermatology, allergology, otorhinolaryngology, respiratory medicine, etc., while AIDS involves dermatology, infectious diseases, CDC and other multidisciplinary disciplines, all of which are important diseases studied jointly by multiple disciplines. Psoriasis, on the other hand, is a true dermatological disease and is a single-disciplinary disease that is currently the focus of dermatological research worldwide. According to incomplete estimates, about 125 million people worldwide are afflicted by psoriasis. The etiology of psoriasis is complex, and the exact cause and pathogenesis are still unclear. In recent years, it is generally believed that psoriasis is related to genetics, infections, environmental factors, metabolic disorders, immune dysfunction, endocrine disorders, and psychiatric factors. Although psoriasis is not contagious, it causes serious double damage to both the mind and body of patients. October 29 is World Psoriasis Day, a truly global event that gives a special holiday to the approximately 125 million psoriasis sufferers internationally. On October 29, the International Federation of Psoriasis Associations and support groups hold events around the world to raise the proper awareness of psoriasis and the people who suffer from it, and to give psoriasis the attention and respect it deserves. Psoriasis has a high incidence, its cause and pathogenesis are unclear, and there are no effective treatment drugs worldwide, making it a Nobel Prize pending disease. Therefore, psoriasis is a challenging worldwide skin disease, for both doctors and patients. However, psoriasis is by no means an incurable disease. Through standardized treatment, psoriasis can fully achieve a therapeutic effect of symptom relief and even long-term non-recurrence.