The most common manifestation of the cardiovascular system in patients with uremia is hypertension. Most patients have varying degrees of hypertension. Hypertension can cause atherosclerosis, left ventricular hypertrophy, and heart failure. As the patient’s renal function continues to deteriorate, the incidence of heart failure increases significantly, and the incidence of heart failure can reach 70% by the time of uremia. When heart failure occurs, the patient may experience dyspnea and inability to lie down. In addition, uremic patients may also develop uremic cardiomyopathy, which is related to the retention of metabolic wastes in the patient’s body and anemia. Uremic pericardial lesions are manifested as pericardial effusion, and patients with severe disease can have symptoms of pericardial pressure, so it is important to pay attention to the manifestations of the cardiovascular system in patients with uremia.