For insomnia patients who cannot sleep for two days and two nights, first of all, we need to clarify what causes insomnia, after which symptomatic treatment can be carried out. Generally for simple insomnia can be improved mainly through daily care, medication, physical therapy and psychotherapy or a combination of these measures: 1. Daily care: First, insomnia patients should maintain a regular daily rest time, and it is generally recommended to go to sleep before 11:00. Second, patients should choose a quiet, warm, dark room with a comfortable sleeping position to sleep, and can listen to soothing music before bedtime to help fall asleep. Finally, patients should avoid drinking coffee, strong tea, alcohol and other stimulating drinks before bedtime, but can consume foods such as red dates, milk, bananas and other foods that help to calm the mind and help to sleep; 2, medication: patients without contraindications can take sleep-aiding drugs under the guidance of doctors, mainly including benzodiazepine receptor agonists, melatonin receptor agonists and so on. However, in order to reduce drug dependence, it is recommended that patients choose the lowest effective amount and take it intermittently and for a short period of time; 3, physical therapy: physical therapy for insomnia includes repetitive transcranial magnetic stimulation, transcranial electrical stimulation, electrostatic stimulation, etc.; 4, psychotherapy: patients should understand the symptoms of insomnia in order to eliminate the negative psychology of anxiety and depression. At the same time, relaxation training, verbal suggestion, situational suggestion and other methods can also be adopted to induce certain psychological effects on the nerves of the brain, thus facilitating sleep. In addition to the above methods, there are some patients with insomnia caused by other diseases, such as depression, nocturia, sleep apnea syndrome, menopause syndrome, cerebrovascular disease, etc. Therefore, it is recommended that patients with insomnia actively search for the cause and carry out symptomatic treatment for the cause to effectively improve insomnia symptoms.