American College of Rheumatology 1997 revised criteria for classification of SLE: 1. Cheek erythema Fixed erythema, flat or elevated, in prominent areas of both cheekbones. 2. discoid erythema lamellar erythema raised above the skin, with adherent keratinous debridement and follicular plugs; atrophic scarring may occur in old lesions. 3.Photosensitivity There is a significant reaction to sunlight, causing a rash, known from the medical history or observed by the doctor. 4, oral ulcers Oral or nasopharyngeal ulcers observed by a physician, usually painless. 5.Arthritis Non-erosive arthritis involving 2 or more peripheral joints with pressure pain, swelling or fluid accumulation. 6. Plasmacytitis Pleurisy or pericarditis. 7. Renal lesions Urine protein >0.5g/24 hours or ++++, or tubular pattern (red blood cells, hemoglobin, granules, or mixed tubular pattern). 8. Neurological lesions Seizures or psychosis, except drugs or known metabolic disorders. 9, Hematologic disorders Hemolytic anemia, or leukopenia, or lymphocytopenia, or thrombocytopenia. 10. Immunologic abnormalities Positive anti-ds-DNA antibodies, or positive anti-Sm antibodies, or positive antiphospholipid antibodies (the latter includes one of three: anti-cardiolipin antibodies, or positive lupus anticoagulant, or a false positive syphilis serologic test lasting at least 6 months). 11. Antinuclear antibodies Abnormal titers of antinuclear antibodies at any time and in the absence of drug-induced “drug-induced lupus”. If four or more of these 11 items are met, SLE can be diagnosed after excluding infections, tumors and other connective tissue diseases.