High total bilirubin, direct bilirubin and indirect bilirubin are likely to be caused by hepatocellular injury. As a result of hepatocellular injury, the uptake, metabolism and excretion of bilirubin by hepatocytes are affected to a certain extent, and the above abnormalities in liver function can occur, which is generally referred to as hepatocellular jaundice in clinical practice. Hepatocellular jaundice includes many diseases, such as viral hepatitis, primary liver cancer, autoimmune liver disease, alcoholic liver disease, drug-related hepatitis, and cirrhosis of the liver. Clinically, different treatments are needed according to different diseases, but theoretically, all of them can be considered to apply liver-protecting and anti-yellowing drugs, such as gardenia yellow oral solution and adenosine methionine, etc. Primary liver cancer should also be considered for timely surgical treatment. If total bilirubin and indirect bilirubin are mainly elevated, the presence of hemolytic jaundice should be considered, while if total bilirubin and direct bilirubin are mainly elevated, the presence of obstructive jaundice should be considered.