Small bumps on the back of the hand hurt when pressed, which may be caused by mosquito bites, folliculitis, tendon sheath cysts, boils and other factors. It is recommended to pay attention to local care and give appropriate internal or external drugs for treatment. 1. Mosquito bites: After the hands are bitten by mosquitoes, the toxins are injected into the body, which may cause allergic reactions, leading to redness, swelling and pain. It is recommended to keep the local clean and hygienic, local application of glycerite lotion and other anti-itching drugs, with the passage of time, can gradually recover. 2. Folliculitis: Folliculitis is mostly caused by bacterial infection. You can take oral doxycycline, amoxicillin, cefixime and other drugs, can promote recovery. 3. Tendon sheath cysts: tendon sheath cysts occur on the back of the hand, the contents of the cyst liquefy and necrolyze, which may cause pain, and pressure leads to aggravation of pain. Diclofenac tablets and cream may be given, which may help relieve pain. 4. Boils: purulent inflammation formed by Staphylococcus aureus invading the deep tissues of hair follicles, accompanied by pain. Oral amoxicillin can be taken, and topical mupirocin ointment and fusidic acid cream can inhibit bacterial metabolism and reproduction and relieve redness, swelling and pain. The back of the hand with small bumps on the pressure pain, it is recommended to go to the hospital dermatology department, a clear diagnosis, under the guidance of the doctor standardized treatment. The above medications should be used in accordance with medical advice.