Fetal spina bifida can usually be diagnosed by ultrasound at 4-5 months. Spina bifida is a type of open neural tube malformation. Among the screening tests during pregnancy, Down’s syndrome screening can be performed at 15-20 weeks of pregnancy. The Down’s test can detect the risk of neural tube defects. If the Down’s test alpha-fetoprotein value is high, there is a high suspicion that the fetus has a neural tube defect. However, the final diagnosis needs to be made by ultrasound at 4-5 months. If a high risk of fetal neural tube defects is detected during Down’s screening, the subsequent 3D or 4D ultrasound examination should focus on checking the fetus for neural tube defects and checking for spina bifida and other malformations. If the fetus has abnormalities, the pregnancy needs to be terminated promptly. It is important to have regular prenatal checkups during pregnancy. If fetal abnormalities are detected, seek prompt medical attention and deal with them under the guidance of your doctor.