Gastrointestinal endoscopy has been used for more than 100 years and is currently the most common and reliable method for diagnosing gastrointestinal diseases and is one of the important treatments for certain gastrointestinal diseases. However, in the past, GI endoscopy was mostly performed under surface anesthesia of the throat only, which caused patients to feel nervous, anxious and fearful, as well as throat discomfort, cough, nausea, vomiting, increased blood pressure, and even induced complications such as angina, myocardial infarction, and cardiac arrest. As a result, some patients are afraid and refuse to undergo this necessary examination or review. Painless gastroscopy is a clinical technique in which a certain dose of sedative is applied during routine gastroscopy, so that the patient has a short sleep during the gastroscopy operation, and the patient immediately wakes up as usual, with no memory of the whole examination process and no painful sensation. The whole examination process is quiet, comfortable and painless for the patient. Practice has proved that painless gastroscopy is a good technique and method that is safe, comfortable and effective. Who are suitable for this examination and who are not? What do you need to pay attention to after the examination? Who are suitable for painless gastroscopy (1) those who need gastroscopy but are afraid of routine gastroscopy; (2) those who have difficulty in completing routine gastroscopy due to severe vomiting or other reasons; (3) those who have other diseases and the condition is very necessary for gastroscopy. Such as those with hypertension, mild coronary heart disease, old myocardial infarction, epilepsy and pediatric patients or psychiatric patients who cannot cooperate. Who are not suitable for painless gastroscopy (l) People who are not suitable for routine gastroscopy in principle are also not suitable for painless gastroscopy; (2) People with history of drug allergy, especially those with history of sedative drug allergy; (3) Pregnant women and lactating women; (4) Diseases that are likely to cause asphyxia, such as: bronchitis causing sputum, gastric retention, acute upper gastrointestinal hemorrhage causing retention of more blood in the stomach; (5) (5) Caution should be exercised for people with severe snoring and excessive obesity; (6) Caution should be exercised for people with bradycardia. Most people wake up immediately after painless gastroscopy, but some people still have slight drowsiness, dizziness, unstable gait and vital signs do not return to the preoperative level immediately after waking up. The following things need to be noted after the examination: (1) someone should accompany you for 3 hours after the operation; (2) you should not ride a bicycle, drive, work at height or operate heavy machinery on the day after the operation to prevent accidents; (3) you should not eat spicy food on the day and avoid drinking alcoholic beverages for 1 to 2 hours.