Discomfort in the liver, but without pain, is clinically referred to as hepatic discomfort and is mainly caused by liver lesions. Certain physiological causes can also cause symptoms of hepatic discomfort, such as overexertion, emotional stress or strenuous exercise, which may cause liver stasis to be more pronounced and thus cause symptoms of hepatic discomfort. Liver discomfort is also an early symptom of many liver lesions, but because many patients do not pay attention to it, the lesions are not diagnosed and treated early, which may cause further aggravation of liver fibrosis and even cirrhosis, delaying diagnosis and treatment. Clinical causes of liver discomfort are mainly seen in viral hepatitis, fatty liver, alcoholic liver disease, cirrhosis, liver cysts, hepatic hemangioma, and even primary liver cancer. When the symptoms of liver discomfort persist, further liver ultrasound and liver function tests should be performed to determine whether there are organic lesions.