Clinically there is no such thing as a one-dose Hepatitis B vaccine. The full hepatitis B vaccination requires three shots. One month after the first injection of hepatitis B vaccine, the second injection should be carried out, and the third injection should be carried out at the age of six months. One month after all three injections are completed, you should go to the hospital to check the two halves of hepatitis B to see if you have antibodies against hepatitis B. If the antibodies are not very high, you may need to take a booster injection. If the hepatitis B vaccine has not been injected three times, hepatitis B surface antibodies may also be produced, but relatively speaking, the maintenance time may not be too long. Therefore, the current requirement for clinical hepatitis B vaccination requires a systematic standardization of three injections. In this way, the chance of producing hepatitis B surface antibody will be higher, and the maintenance time will also be relatively long. People who need to be vaccinated against hepatitis B vaccine should go to regular hospitals in time, be vaccinated by professional doctors after eliminating contraindications to vaccination, and pay attention to observing skin manifestations and other adverse reactions after vaccination.