Whether or not to take medication for mild insulin resistance should be evaluated in conjunction with the blood glucose level, if the blood glucose value rises to the diagnostic standard of diabetes, then it is necessary to comply with the doctor’s instructions to take medication, if the blood glucose value is normal, there is no need to take medication for the time being. Insulin resistance is an important link in the pathogenesis of type 2 diabetes mellitus, patients with insulin resistance can maintain normal blood glucose if the pancreatic B-cells are able to increase insulin secretion compensatory, if the patient’s pancreatic B-cells can’t compensate for the insulin resistance, it may cause type 2 diabetes mellitus. If patients with insulin resistance have fasting blood glucose greater than or equal to 7mmol/L or glucose tolerance test two hours greater than or equal to 11.1mmol/L and have typical symptoms of diabetes mellitus, it is necessary to consider the use of glucose-lowering drugs such as acarbose, metformin, etc., and at the same time, appropriate physical exercise, good dietary control. For insulin resistance patients with normal blood glucose value, there is no need for medication, good dietary control, and appropriate physical exercise, such as jogging, swimming, etc., to increase insulin sensitivity. Patients with mild insulin resistance should go to the hospital and ask the doctor to judge whether they need medication according to their own conditions.