Small transparent blisters on children’s hands may be due to eczema, hand, foot and mouth disease, sweat herpes and other causes, can be treated through daily care, medication and other methods. 1. eczema: acute stage of vesicles, oozing can be used boric acid solution for wet compresses, oozing relief can be used hydrocortisone butyrate cream and other glucocorticosteroids topical application. Oral loratadine tablets, cetirizine hydrochloride drops and other antihistamines can also be used for treatment. 2. Hand-Foot-Mouth Disease (HFMD): During the onset of the disease, we should pay attention to isolation, avoid cross-infection, take a light diet, avoid spicy and stimulating food, and pay attention to rest. If necessary, recombinant human interferon a1b injection and other drugs can be used for treatment. 3. Sweat herpes: you can choose to use tretinoin ointment, tacrolimus ointment and other anti-inflammatory treatment under the guidance of a professional physician, and when itchy symptoms occur, you can use antihistamines such as loratadine tablets for external application. Parents are advised to take their children to the hospital in time for relevant examinations, to identify the cause of the disease, under the guidance of professional physicians for targeted treatment.