There are many treatment methods for anal fissure, and injection therapy is one of the more commonly used methods. In the past, simple closed treatment was used, but in recent years, different injectable drugs have been developed for the treatment of anal fissure, and better results have been received. Closed therapy The closed therapy of anal fissure is to inject anesthesia drugs and long-lasting painkillers into the lesion and its surrounding tissues to relieve pain and spasm of sphincter muscle, so that the wound of fissure can be repaired. Commonly used anesthetic drugs are procaine, lidocaine, bupivacaine and dicaine, and long-acting painkillers generally use methylene blue injection. Alcohol closure method Some people in the fissure successive injection of procaine and alcohol, can relieve pain and sphincter spasm, so that the fissure healing. The method is 0.5~0.7cm at the outer end of the anal fissure into the needle, injected 1-2% procaine 10ml, infiltrated in the anal subcutaneous tissues and part of the sphincter; followed by 70-96% alcohol lml injected into the fissure damage under 0.8 llm depth. This method has significant effect on the initial stage of anal fissure. Hormone closure method Some scholars used prednisolone to close the treatment of old anal fissure in 45 cases, 40 cases were cured, 5 cases were effective; the cure time was 6-30 days, the average was 13 days; the number of injections was 1-4 times, the average was 2.4 times. Injection method: lying on the side, take prednisolone suspension (lml prednisolone injection plus 2% procaine 4~5ml) l~2ml, fan-shaped injection into the anal fissure on both sides of the sphincter and the base of the anal fissure. After injection, rub and press for a moment. For those with anal canal stenosis, anal dilatation can be done at the same time. Acupuncture point closure method: Long-acting pain reliever should be injected into the patient’s long-strength points in a fan-shaped manner once every other day, with 5 times as a course of treatment. This method is less effective for old anal fissure. Methods: Take the side lying position, take 6ml of Chuan Bending Voice Injection at Changqiang point, add 2ml of l% procaine to close the point. This method plays a continuous stimulation of meridians, inhibit sphincter spasm, improve local blood circulation, promote the role of wound healing. The elimination of hemorrhoidal spirit plus closed method Some scholars use the elimination of hemorrhoidal spirit injection to treat 42 cases of anal fissure, so that the pain is reduced or disappeared, the stool is normal. Recent follow-up, no recurrence. Injection method: first 1% procaine 2 ml, anti-hemorrhoidal spirit 2 ml, formulated into 1:1 liquid, injected at the base of the fissure, and then 1% procaine 4 ml, 4 ml of the United States blue, respectively, in the anus at 3, 9 points vertical injection of 3 to 4 ml. anti-hemorrhoidal spirit has anti-inflammatory, analgesic, hemorrhagic effect, the latter for the long-lasting analgesic agent.