Primary central nervous system lymphoma is a rare malignant tumor, which is a non-Hodgkin’s lymphoma occurring in the extranodal area, causing obvious abnormalities of the nervous system function, and the clinical treatment options mainly include surgery, radiotherapy and symptomatic treatment. 1. Surgery: for the tumor that causes obvious increase of intracranial pressure or single huge tumor, local resection can be performed through craniotomy. 2. Radiotherapy: primary CNS lymphoma can be controlled by standardized application of chemotherapeutic drugs, commonly used drugs include methotrexate. This disease usually does not adopt pure radiotherapy as the initial treatment, but mostly adopts adjuvant radiotherapy or late radiotherapy after chemotherapy. Localized radiotherapy can be applied to the lesion, which can help to relieve the symptoms. 3. Symptomatic treatment: mainly through the use of drugs to alleviate the symptoms, the presence of increased intracranial pressure can be applied mannitol or furosemide to reduce intracranial pressure. If primary CNS lymphoma is found in clinic, it is necessary to consult doctor for observation in time, and after determining the specific lesion condition through MRI, standardized treatment should be carried out under the guidance of clinician, so as not to be careless and negligent, so as not to delay the condition.