The most common disease that can make the urine protein turn negative is nephrotic syndrome. Nephrotic syndrome is an immune-related disease, after the immune damage to the kidney, there will be sterile inflammation, therefore, the application of antibiotics is not effective, you need to apply hormone and immunosuppressive therapy, the more commonly used hormones are methylprednisolone and prednisone, more commonly used immunosuppressive drugs are cyclophosphamide and tacrolimus. If the urine protein turns negative after the above treatment, it indicates that the pathological type of the kidney is better and more sensitive to hormones and immunosuppressants. The next step is to continue the treatment for maintenance. However, it should be emphasized that even urine protein metastasis has the possibility of recurrence, especially when patients are tired, have low resistance, get cold, flu, infection and fever, so patients must pay attention to keep warm and avoid exertion.