The knee joint is a joint of great effort in the human body because it is subjected to the most pressure, has the widest range of motion, and is a strong guarantee of the normal function of the lower limbs. Generally speaking, the knee joint is an organic unity of the femoral, tibial and patellofemoral articular surfaces that make up the joint during walking, and unevenness and increased friction of the articular surfaces due to any factor can lead to joint discomfort and dysfunction. In young people, the majority of knee discomfort or dysfunction is caused by sports injuries, however, middle-aged and elderly people, especially women, often experience knee pain unconsciously, especially when walking up or down stairs, but no significant pain when walking on level ground. This condition is not noticed because it is not painful to walk on level ground. Even so, because of the fear of knee problems, some patients will go to the hospital, but sometimes the answer they get is that there are no abnormal changes in the x-ray, and the non-specialist doctors also think that it is an age-related change and there is no good way to treat it, but just take some painkillers or physical therapy and other treatments, and generalize. As an expert in joint surgery, with three decades of experience in clinical diagnosis and treatment of knee diseases and related research, I am very happy to propose scientific and standardized preventive diagnosis and treatment measures to the general public here as follows: 1, unexplained knee pain, not red or swollen, and only upstairs pain or downstairs pain, at this time is often a problem with the patellofemoral joint surface, commonly known as cartilage surface roughness, at this time, if handled in a timely manner, the patient is often in 1 year. At this time, if the treatment is timely and appropriate, the patient’s symptoms often disappear within 1 week or even less. Unfortunately, in my clinical experience, most patients often come to the doctor only after a month, two months or even six months of pain, so, as you can imagine, the initial roughness of the cartilage surface becomes uneven over time due to lack of proper treatment, and the opportunity for early treatment is obviously lost. For this reason, patients with knee pain are urged to see a specialist outpatient clinic specializing in joints as early as possible to avoid receiving informal treatment and delaying the best time for treatment. 2. The so-called best time for treatment is early treatment, standardized treatment and effective treatment. Early knee pain (within 1 month), should be timely supplemented with joint nutrient fluid, currently the clinical common use of domestic or imported hyaluronic acid, commonly known as joint lubricant. Generally, intra-articular injections are given once a week for a course of 3-5 weeks, while oral cartilage supplements are used for better results. The entire course of treatment is about 1 to 2 months. For those with a disease duration greater than 1 month and less than 1 year, it is often attributed to mid-term knee pain, mostly due to the evolution of neglecting early treatment. Treatment is still preferred with intra-articular lubricant injections and oral cartilage supplements, but the course of treatment will be extended accordingly. After the above treatment, for some joints with swelling and friction sounds, and the symptoms have not improved, at this time, arthroscopic minimally invasive cleanup should be used promptly, and most patients can obtain satisfactory results. 3.For elderly patients with a disease duration of up to 1 year or even longer, different surgical interventions can still be selected according to the imaging performance, thus delaying the further destruction of the articular cartilage surface, commonly including brace wearing of corrective force lines, surgical correction and surface replacement of the articular surface. 4. In addition to the formal treatment mentioned above, patients should also avoid sports and lifestyle habits that aggravate joint wear, such as: no climbing, no hiking, no tai chi, and instead, take walks, swim or non-weight bearing knee exercises, such as pedaling in place. In conclusion, joint pain is an unavoidable topic for middle-aged and elderly people. We hope that those who have read this article will gain the knowledge of proper joint protection and avoid cartilage degeneration, as well as accept the latest sequential treatment concept mentioned above, so that they can have a healthy joint proportional to their age.