Headache after radiotherapy for nasopharyngeal carcinoma is a relatively common situation, as follows: 1. The most common site of invasion of nasopharyngeal carcinoma is skull base. If the patient still has pain after radiotherapy, it may be necessary to consider whether the disease is well controlled or not. 2. Factors caused by treatment, besides treating the lesion, radiotherapy will also damage the surrounding tissues and organs, for example, damage to temporal lobe brain tissue, which may cause brain edema or even brain necrosis after radiotherapy, which will also cause severe headache and requires active treatment. If brain necrosis is caused by radiotherapy, surgical intervention is still needed; 3. If pain occurs relatively long after radiotherapy, it is still necessary to suspect whether it is a local recurrence of nasopharyngeal cancer, and regular review should be conducted regularly for early detection and early treatment to achieve better treatment effect.