Patients with thyroid nodules can receive a third dose of the New Crown vaccine, which is usually not recommended if the patient had an adverse reaction to the first two doses. Patients with thyroid nodules can usually receive a third dose of the New Crown vaccine. The third dose is a booster shot, which usually has no effect on the condition and does not lead to worsening of the nodules, and there are no thyroid nodules among the contraindications for the New Crown vaccine. If patients with thyroid nodules have adverse reactions to the first two doses of the New Crown vaccine, it is usually not recommended. If the vaccine is needed, it is recommended to consult a medical professional and have the vaccine administered under the guidance of a doctor. Patients with severe liver and kidney diseases, malignant tumors, severe cardiovascular diseases, bleeding disorders, etc., if their conditions are not well controlled, it is not recommended to administer the New Crown Vaccine, and the vaccination should be administered after their conditions have stabilized. Therefore, if patients with underlying diseases themselves, it is recommended that they consult a doctor before receiving the New Crown vaccine and be vaccinated under the doctor’s guidance to avoid adverse consequences.