A high creatinine level usually does not cause recurrent fevers. If it is combined with an infectious disease, it may cause a fever. High creatinine can be physiologic or pathologic. Physiological reasons, such as high muscle content, or eating more meat and exercising more, usually have no symptoms; pathological reasons, such as acute kidney injury, chronic renal insufficiency, mainly manifested as edema, shortness of breath, nausea, vomiting, loss of appetite, etc., and only in combination with infectious diseases will it manifest as fever. Repeated fever is mostly seen in infectious diseases, often accompanied by various systemic infections, respiratory infections are often accompanied by coughing, coughing up sputum, wheezing, etc.; urinary system can be seen in urinary frequency, urinary urgency, urinary pain, etc.; digestive system can be seen in abdominal pain, diarrhea and so on. Blood routine can suggest that the percentage of white blood cells and neutrophils are elevated. If the patient with high creatinine has a recurring fever, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.