A Handan native is only 33 years old, originally a sunny age, but since he learned that he has hepatitis B, his life has fallen to the ground and he is under great pressure, and he is in the grey shadow of hepatitis B all day long. His mood fluctuated with the high and low liver function indicators, and he was either happy or sad. This is a painful situation for you. In the end, the disease is not cured, but the heart and economic burden is increased. What should I do if I have hepatitis B? Chronic hepatitis B is caused by infection with the hepatitis B virus, because of the special nature of its infection, a complete cure is unrealistic, but with the development of medical science, control the development of the disease, is not a luxury! Several large series of long-term studies have shown a strong relationship between the level of HBV viral load and its progression to cirrhosis and liver cancer, thus also suggesting that continuous suppression of viral replication is the key to treatment. The guidelines for the treatment of liver disease set by state liver societies around the world are basically the same, namely: long-term sustained suppression of viral replication to reduce or delay the onset of liver inflammation and fibrosis, reduce the incidence of cirrhosis and liver cancer, and improve quality of life. That’s why antiviral therapy is imperative! How to carry out antiviral? First, a comprehensive assessment of the patient is needed. Including, past history, family history, exposure history, life history, relevant laboratory tests and impactology, past treatment received, and concomitant diseases. Based on the patient’s specific situation, an appropriate treatment plan is selected. Close cooperation between doctor and patient to maintain compliance and to inform how to maintain good lifestyle habits and the importance of regular follow-up. Second, the choice of drugs. Interferon and nucleoside analogues are the two main types of drugs currently used in clinical practice. Interferon is preferred by health care professionals for its efficacy and short course of treatment, but its application is limited by its side effects and poor tolerability due to long-term intramuscular injection. The duration of treatment is generally 6 to 12 months, and patients who do not achieve a complete response can be treated in a discontinuation-observation-drug cycle to continuously control the progression of the disease. Nucleoside analogs have an irregular course, cannot be discontinued, and their resulting drug resistance has received increasing attention in recent years. De-treated patients should choose strong high genetic barrier entecavir for treatment in order to reduce the incidence of drug resistance, thus preventing entry into the vicious cycle of drug resistance-addition-against-drug resistance and economic and psychological burden at home. Some reports showed that after 3 years of entecavir, 93% of patients with HBVDNA reached undetectable values or less, and after 3-6 years of entecavir, 96% of patients had different improvements in pathology and fibrosis. Stable disease with normal ALT and minimal risk of disease progression. Emphasis on the removal of treatment, the correct understanding of the disease, the establishment of the correct concept of prevention, long-term inhibition of viral replication, control of disease development, not to short-term goals for improvement, the establishment of rational long-term prevention and treatment goals, in order to liberate themselves, have a healthy mentality, better integration into society, work and study.