CRP refers to C-reactive protein. High white blood cells but normal C-reactive protein may be caused by leukemia, myelofibrosis and other diseases. 1. Leukemia: it is a kind of malignant clonal disease of hematopoietic stem progenitor cells. Clinical symptoms such as anemia, bleeding, infection, fever, and enlargement of liver, spleen, lymph nodes, and bone pain in different degrees can be seen, which will lead to high white blood cells and normal C-reactive protein. 2. Myelofibrosis: Myelofibrosis is a myeloproliferative disease in which the hematopoietic tissue of bone marrow is replaced by fibrous tissue. It is a myeloproliferative disease in which the fibrous tissue severely affects the hematopoietic function. In the early stages, it can also lead to high white blood cells and normal C-reactive protein. A high white blood cell count with normal C-reactive protein that continues unabated requires prompt medical attention to determine the cause of the disease.