There is no concept of the best time to take Tibolone, but it is recommended that it be taken at the same time each day. The main ingredient of Tiberone is estrogen, which is often used as a replacement therapy for estrogen deficiency in postmenopausal women to improve menopausal symptoms and is commonly used in the treatment of women during menopause. Generally, it is recommended to take Tibolone at a fixed time every day. Most patients can get better symptoms after taking it for a few weeks, and can get better results after 3 months of continuous use. This drug should be taken under the guidance of an obstetrician and gynecologist and should not be taken on its own. It should be noted that tibolone may cause adverse reactions such as vaginal bleeding, so it should not be used during pregnancy, lactation, or in patients with unexplained vaginal bleeding. In addition, tibolone can also damage liver function and should be avoided in patients with impaired liver function.