How to count the solid component of mixed ground glass nodules

The solid component of mixed ground glass nodules is usually measured at the largest diameter to serve as a reference value, or a threshold segmentation method can be used to calculate the volume or percentage using software. Mixed ground-glass nodules are lung nodules that have both a solid and a ground-glass component and have a higher risk of malignancy, approximately 63%. The more solid components, or increased solid components, of mixed ground glass nodules, the higher the likelihood that they are lung cancer. The solid component of a mixed ground-glass nodule can be estimated by manually measuring the maximum diameter of the solid component, but there is some subjective error. Nowadays, it is also possible to set the CT threshold of the solid component to extract the solid component, and rely on volumetric software to calculate the volume and percentage of the solid component. Mixed ground-glass nodules with a solid component >6 mm generally carry a certain risk of malignancy, and the more solid components, the higher the probability of malignancy. Patients are advised to consult a specialist for a comprehensive interpretation of the imaging report and to follow the doctor’s instructions for further investigation and treatment.