The lack of ejaculation pleasure may be caused by diseases, drug factors, surgical operations, mental and psychological factors, etc. Any interference with the center controlling ejaculation or the autonomic nerves of the spermatic tract may lead to the lack of sexual pleasure. Ejaculation pleasure is dominated by the center of ejaculation (including the spinal cord level or supraspinal level) and the autonomic nerves of the spermatic tract, therefore, any factor that may interfere with the above mentioned nerves may lead to the situation. Including ① diseases: such as prostatitis, erectile dysfunction, etc.; ② drug factors: such as clozapine and other antidepressants; ③ surgical operations, such as colon, rectum and anus surgery, etc., which can make the nerves innervating the bladder neck malfunction. ④ mental psychological factors: certain adverse psychological activities, such as concerns about their own sexual function problems, poor environmental conditions of sexual life, etc., will be through the cerebral cortex, directly affecting the ejaculatory pleasure. In addition, ejaculation without pleasure may be caused by other reasons, it is recommended to go to the hospital in a timely manner, to identify the causes of targeted treatment.