The specific etiology of pancreatic malignant tumor at present is still not clearly studied clinically, which fully reflects the complexity of pancreatic malignant tumor. However, after a large amount of clinical data, the high-risk factors of pancreatic malignant tumor are mainly the following, which we all learn together below. All clinical diseases or habits that cause damage to the pancreatic parenchyma may cause the development of pancreatic malignant tumor: 1, smoking and drinking alcohol, alcohol can cause damage to the pancreatic parenchyma cells, in addition, alcohol can cause spasm of the duodenal papilla, which can lead to obstruction of pancreatic fluid excretion. The accumulation of pancreatic fluid can cause dilation of the pancreatic duct, which can join the damage of the pancreas. Smoking can cause continuous constriction of the blood supply vessels of the pancreas, leaving the pancreatic cells in a state of ischemia and hypoxia, which is not conducive to faster recovery of damaged pancreatic cells. Thus, causing the occurrence of malignant tumors of the pancreas. 2, repeated episodes of acute pancreatitis, repeated episodes of pancreatitis will cause serious damage not only to the pancreatic tissue, but also to the tissues and organs around the pancreas. The activated pancreatic enzymes often cause irreversible damage to the pancreatic parenchyma, which is an important factor in the development of pancreatic malignant tumors. 3. Patients with chronic pancreatitis are often accompanied by the formation of pancreatic duct stones. The repeated stimulation and friction of pancreatic duct stones in the pancreatic duct will cause lesions in the mucosa of the pancreatic duct, which will eventually lead to the occurrence of malignant tumor. 4, Some patients due to the backflow of intestinal fluid into the pancreatic duct, because enteritis is alkaline, accompanied by a certain corrosive effect, can cause different degrees of damage to the mucosa of the pancreatic duct and the pancreatic parenchyma cells. Once the damaged pancreatic tissue cannot be fully recovered, it may develop into malignant tumor.